Medicinal Chemistry

Course: M.Sc. Code: KL-442 Branch: Chemistry Year: 2023

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Roll No. ..............
Total No. of Questions : 11
Total No. of Printed Pages : 7
KL-442
M. Sc. (Sem. IV)
Regular/Private/ATKT/Old ATKT/EX
Examination - May, 2023
CHEMISTRY
Paper E
Medicinal Chemistry
Time : 3 Hours
Maximum Marks : 85
Minimum Pass Marks : 31
Note : Attempt all questions.
Section A
5x2=10
Objective Type Questions
1.
Choose the correct answer :
(i)

Which of the following physico-chemical properties is least commonly considered in QSAR sites?

  • (a) Hydrophobicity
  • (b) Electronic influence of substituents
  • (c) Dipole moment
  • (d) Size of substituents
(ii)

The action of the drug on the body is known as :

  • (a) Pharmacokinetics
  • (b) Pharmacodynamics
  • (c) Pharmacology
  • (d) Pharmacotherapeutics
(iii)

Which among the following antibiotic function as protein synthesis inhibitors ?

  • (a) Penicillin
  • (b) Tetracyclin
  • (c) Cefotaxime
  • (d) Trimethoprim
(iv)

Which antifungal drug is most effective with a broad spectrum ?

  • (a) Fluconazole
  • (b) Flucytosine
  • (c) Caspofungin
  • (d) Anidulafungin
(v)

NSAIDS combat fever by inhibiting which prostaglandin ?

  • (a) Prostaglandin Eā‚‚
  • (b) Prostaglandin Iā‚‚
  • (c) Prostaglandin Dā‚‚
  • (d) Prostaglandin Fā‚‚
Section B
5x5=25
Short Answer Type Questions
2.

What do you mean by SAR ?

Or

Explain factors affecting bioactivity.

3.

Write note on any one of the following :

(a)

Enzyme inhibition

(b)

Sulfonamides

Section C
5x10=50
Long Answer Type Questions
4.

Write synthesis and mode of action of any one of the following :

(a)

Tetracyclin

(b)

Cephalosporins

5.

What is antifungal drug ? Write the synthesis of Ciprofloxacin.

Or

Give the synthesis of chloroquine.

6.

Write short note on any one of the following :

(a)

Ibuprofen

(b)

Salbutamol

7.

Write short notes on any two of the following :

(a)

Combination synthesis in drug discovery

(b)

Receptor site theory

(c)

Free-Wilson analysis

(d)

Hansch analysis

8.

Discuss the different types of bio-transformations with suitable examples.

Or

Give the significance of drug metabolism in medical chemistry.

9.

Write brief note on any one of the following :

(a)

Anticancer

(b)

Antitubercular

10.

Write brief note on any one of the following :

(a)

Antiviral drugs

(b)

Chemotherapy of Malaria

11.

Explain in detail non-steroidal anti-inflammatory drugs.

Or

Describe various agents of anti-asthmatic drugs.